Primobolan
(Methenolone acetate) is a synthetic, orally active anabolic-androgenic steroid
and dihydrotestosterone (DHT) derivative. It can be used for the treatment of
bone marrow disease and anemia. Methenolone acetate is known for its higher
therapeutic efficiency and lower hepatic toxicity compared with its 17 alpha-
alkylated analogs. Methenolone cannot aromatize to estrogen, reducing
estrogenic side effects, and has a favorable safety profile among anabolic
agents.
Methenolone acts upon
the androgen receptor stimulating anabolism through increased nitrogen
retention and protein synthesis in muscle tissue. Methenolone acetate in a
single dose pharmacokinetic study has demon strated a mean elimination
half-life of 6 days.
Indications
As an alternate or
adjunctive therapy in patients for the promotion of weight gain following
weight loss and/or muscular atrophy associated with extensive surgery, chronic
infections, long term hospitalization, or severe trauma. To
compensate for protein catabolism consequent to corticosteroid therapy.
